Lymphocytic Vasculitis : Classification of 127 cases
Abstract
Aim. Lymphocytic vasculitis is a morphological term which includes clinically heterogenous diseases like connective tissue disease, infection, lichenoid diseases, drug reaction, Behçet’s disease, superficial thrombophlebitis and leukemic vasculitis. There are three forms of lymphocytic vasculitis : angiodestructive form, lichenoid lymphocytic vasculitis and lymphocytic endovasculitis. There is a need to classify the diseases with the pathologic diagnosis of lymphocytic vasculitis.
Materials and Methods. In this study, 127 cases of lymphocytic vasculitis diagnosed between 2001-2013 were classified according to the clinical setting. The histopathological diagnosis was given to the lesions with angiotropism/diapedesis by lymphocytes, erythrocyte extravasation and swelling of endothelial cells, with/without fibrinoid necrosis of the vessel wall.
Results. Clinical diagnoses were collagen vascular disease (CVD, n=25; including 6 dermatomyositis, 2 chillblain lupus, 2 morphea), urticarial/leukocytoclastic vasculitis (n=16), pitriazis lichenoides (n=15), drug reaction (n=9), Behçet's disease (n=8), figurate erythema (n=8), panniculitis (n=8), lichen planus (n=7), erythema multiforme (n=6), pigmented purpuric dermatitis (n=5), PUPPP (n=4), Gianotti-Crosti syndrome (n=4), FMF (n=3), spongiotic dermatitis (n=3), arthropod bite (n=2) and 4 other dermatoses.
Conclusions. Lymphocytic vasculitis is believed by some to be the late manifestation of LCV or a non-specific feature but some dermatoses without the characteristic defining pathologic criteria can be diagnosed by this finding. Finding lymphocytic vasculitis in CVD can be a hint for the endothelial cells to be a target, too.
Aim. Lymphocytic vasculitis is a morphological term which includes clinically heterogenous diseases like connective tissue disease, infection, lichenoid diseases, drug reaction, Behçet’s disease, superficial thrombophlebitis and leukemic vasculitis. There are three forms of lymphocytic vasculitis : angiodestructive form, lichenoid lymphocytic vasculitis and lymphocytic endovasculitis. There is a need to classify the diseases with the pathologic diagnosis of lymphocytic vasculitis.
Materials and Methods. In this study, 127 cases of lymphocytic vasculitis diagnosed between 2001-2013 were classified according to the clinical setting. The histopathological diagnosis was given to the lesions with angiotropism/diapedesis by lymphocytes, erythrocyte extravasation and swelling of endothelial cells, with/without fibrinoid necrosis of the vessel wall.
Results. Clinical diagnoses were collagen vascular disease (CVD, n=25; including 6 dermatomyositis, 2 chillblain lupus, 2 morphea), urticarial/leukocytoclastic vasculitis (n=16), pitriazis lichenoides (n=15), drug reaction (n=9), Behçet's disease (n=8), figurate erythema (n=8), panniculitis (n=8), lichen planus (n=7), erythema multiforme (n=6), pigmented purpuric dermatitis (n=5), PUPPP (n=4), Gianotti-Crosti syndrome (n=4), FMF (n=3), spongiotic dermatitis (n=3), arthropod bite (n=2) and 4 other dermatoses.
Conclusions. Lymphocytic vasculitis is believed by some to be the late manifestation of LCV or a non-specific feature but some dermatoses without the characteristic defining pathologic criteria can be diagnosed by thisKeywords
Full Text:
READ AS PDFReferences
Weedon D. Skin Pathology. New York, NY: Churchill Livingstone; 2010.
Kossard S. Defining lymphocytic vasculitis. Personal Review. Australas J Dermatol 2000; 41: 149–155.
LeBoit PE. The Enigma of Lymphocytic Vasculitis. Arch Dermatol 2008;144 (9): 1215-1216
Carlson JW, Chen K. Cutaneous Vasculitis Update: Neutrophilic muscular
vessel and eosinophilic, granulomatous, and lymphocytic vasculitis syndromes. Am J Dermatopathol 2007; 29: 32–43
Carlson JW. The histological assessment of cutaneous vasculitis. Histopathology 2010; 56: 3–23.
Guitart J. ‘‘Lymphocytic vasculitis’’ is not urticarial vasculitis. J Am Acad Dermatol 2008; 59(2): 353.
Trevin J, Prieto VG, Hearne R, Polk A, Diwan H. Atypical lymphocytic reaction with epidermotropism and lymphocytic vasculopathic reaction (lymphocytic vasculitis) after treatment with imiquimod. J Am Acad Dermatol 2006;55(5): S123-5
Refbacks
- There are currently no refbacks.
Copyright 2015-2017, Hellenic Society of Pathology
ISSN: 2459-3443