Granulomatous Slack Skin with an unusually aggressive course due to the subsequent development of a CD30-positive Large Cell Lymphoma

Granulomatous Slack Skin with an unusually aggressive course due to the subsequent development of a CD30-positive Large Cell Lymphoma

Alexandra Papoudou-Bai, Eleni Kapsali, Ioannis Kostas Agnantis, Anna Goussia, Anna Batistatou, Dimitrios Stefanou, Panagiotis Kanavaros


Objective: To report a case of Granulomatous Slack Skin with an unusually aggressive course.

Clinical Presentation and histopathology: The patient presented with soft tissue masses accompanied by pendulous lax skin in the upper thighs and the left inguinal region. The clinical findings and the dermal infiltration by CD3+/CD4+ small lymphoid cells led to the diagnosis of Granulomatous Slack Skin. Three years later the bone marrow was infiltrated by a CD30+ Large Cell Lymphoma which resulted in patient’s death.

Conclusion: This case of Granulomatous Slack Skin presents a fatal course due to the development of a CD30+ Large Cell Lymphoma. 


Cutaneous T-cell lymphomas, Granulomatous Slack Skin, Mycosis Fungoides, CD30-positive Large Cell Lymphoma

Full Text:



Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH et al. WHO-EORTC classification for cutaneous lymphomas. Blood 2005;105:3768-3785.

Kempf W, Ostheeren-Michaelis S, Paulli M, Lucioni M, Wechsler J, Audring H et al. Granulomatous mycosis fungoides and granulomatous slack skin: a multicenter study of the Cutaneous Lymphoma Histopathology Task Force Group of the European Organization For Research and Treatment of Cancer (EORTC). Arch Dermatol 2008;144:1609-1617.

Scarabello A, Leinweber B, Ardigó M, Rütten A, Feller AC, Kerl H et al. Cutaneous lymphomas with prominent granulomatous reaction: a potential pitfall in the histopathologic diagnosis of cutaneous T- and B-cell lymphomas. Am J Surg Pathol 2002;26:1259-1268.

Burg G, Kempf W, Cozzio A, Feit J, Willemze R, S Jaffe E et al. WHO/EORTC classification of cutaneous lymphomas 2005: histological and molecular aspects. J Cutan Pathol 2005;32:647-674

Rambhia KD, Haldar S, Dongre AM, Khopkar US. Granulomatous slack skin with systemic involvement and a fatal outcome in an adolescent. Clin Exp Dermatol 2014;39:653-654.

Shah A, Safaya A. Granulomatous slack skin disease: a review, in comparison with mycosis fungoides. J Eur Acad Dermatol Venereol 2012;26:1472-1478.

Song SX, Willemze R, Swerdlow SH, Kinney MC, Said JW. Mycosis fungoides: report of the 2011 Society for Hematopathology/European Association for Haematopathology workshop. Am J Clin Pathol 2013;139:466-490.

Ikonomou IM, Aamot HV, Heim S, Fosså A, Delabie J. Granulomatous slack skin with a translocation t(3;9)(q12;p24). Am J Surg Pathol 2007;31:803-806.

Benton EC, Morris SL, Robson A, Whittaker SJ. An unusual case of granulomatous slack skin disease with necrobiosis. Am J Dermatopathol 2008;30:462-465.

Gadzia J, Kestenbaum T. Granulomatous slack skin without evidence of a clonal T-cell proliferation. J Am Acad Dermatol 2004;50: S4-8.


  • There are currently no refbacks.

Copyright 2015-2017, Hellenic Society of Pathology
ISSN: 2459-3443