Immunohistochemical Investigation of β-catenin Expression in Renal Cell Carcinoma

Immunohistochemical Investigation of β-catenin Expression in Renal Cell Carcinoma

Ioanna Valasopoulou, Aliki Liakea, Nikolaos Katsoulas, Eirini Thymara, Nikolaos Kavantzas, Andreas Ch Lazaris


Renal cell carcinoma is the most common renal malignancy and accounts for approximately 5% of all cancer diagnoses in adults. One of the molecular mechanisms that have been implicated to play an important role in renal cell carcinogenesis is the disregulation of Wnt signaling pathway, reflected by the abnormal expression of beta-catenin. For the purpose of our study, we selected twenty (20) cases of renal cell carcinomas of clear cell, papillary and chromophobe types, confirmed through pathological reevaluation, in order to assess the expression levels of β-catenin. Immunohistochemical staining with anti-β-catenin specific monoclonal antibody was performed. Our study provides hints of the involvement of β-catenin in renal cell oncogenesis.


Renal cell carcinoma, immunohistochemistry, β-catenin

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