Maspin immunoreactivity in salivary pleomorphic adenomas
Abstract
Aim Maspin is a serine protease inhibitor with possible suppressive effects over tumor progression. The aim of this study was to describe maspin expression pattern in pleomorphic adenomas of the salivary glands, in order to investigate the potential role of this molecule in the benign nature of this neoplasm.
Materials and Methods Immunohistochemistry staining was applied in a sample of 120 pleomorphic adenomas and also in 10 adenoid cystic carcinomas, which served as a control group of malignant biphasic tumors.
Results All pleomorphic adenomas exhibited a strong selective positivity of their myoepithelial component, while luminal cells were invariably not immunostained. On the contrary, all adenoid cystic carcinomas presented a negative profile for maspin, predominantly in the highly malignant areas with a solid pattern of development.
Conclusion It is suggested that maspin expressed selectively by myoepithelial cells of pleomorphic adenomas, may function as a tumor- suppressor factor in salivary neoplasia.
Keywords
Full Text:
READ AS PDFReferences
Bodenstine TM, Seftor REB, Khalkhali-Ellis Z, Seftor EA, Pemberton PA, Hendrix MC. Maspin: molecular mechanisms and therapeutic implications. Cancer and Metastasis Reviews 2012;31(3-4): 529–551.
Costa AF, Demasi AP, Bonfitto VL, Bonfitto JF, Furuse C, Araújo VC et al.Angiogenesis in salivary carcinomas with and without myoepithelial differentiation. VirchowsArchiv 2008;453(4): 359-67.
Nguyen M, Lee MC, Wang JL, Tomlinson JS, Shao ZM, Alpaugh ML et al.The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype. Oncogene 2000;19(31): 3449–59.
Tampouris AI, Kandiloros D, Giotakis I, Gakiopoulou H, Lazaris AC. The role of the VEGF-C/-D/flt-4 autocrine loop in the pathogenesis of salivary neoplasms. Pathology, Research and Practice 2012;208(3): 151–6.
Soares AB, Altemani A, de Oliveira TR, de Oliveira Fonseca Rodrigues F, Ribeiro-Silva A, Soave DF et al. Comparison of the Blood and LymphaticMicrovesselDensity of PleomorphicAdenoma and Basal CellAdenoma. ClinicalMedicine Insights Pathology 2015;8: 17-21.
Martins MT, Altemani A, Freitas L, Araújo VC. Maspin expression in carcinoma ex pleomorphic adenoma. Journal of Clinical Pathology 2005;58(12): 1311–4.
Soares AB, Juliano PB, Araujo VC, Metze K, Altemani A. Angiogenic switch during tumor progression of carcinoma ex-pleomorphic adenoma. VirchowsArchiv 2007;451(1): 65–71.
Refbacks
Copyright 2015-2017, Hellenic Society of Pathology
ISSN: 2459-3443